Tuftsin diacetate

CAS No. 72103-53-8

Tuftsin diacetate ( )

Catalog No. M30544 CAS No. 72103-53-8

Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tuftsin diacetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages.
  • Description
    Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages.(In Vitro):Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors.
  • Synonyms
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72103-53-8
  • Formula Weight
    620.7
  • Molecular Formula
    C25H48N8O10
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40.
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